Ms CD127 BV421 A7R34 50ug
货号：
566377 基本售价：
4700.0 元 规格：
50ug
产品信息
概述| 货号 | 566377 |
| 描述 | The A7R34 monoclonal antibody specifically binds to mouse CD127 which is also known as the Inter leukin-7 Receptor alpha chain (IL-7Rα ). CD127 associates with CD132 ( common γ chain ) to form a high-affinity signaling IL-7R complex that mediates the biological functions of IL-7. CD127 can also complex with the Thymic Stromal Lymphopoietin Receptor (TSLPR) subunit to bind and mediate cellular responses to TSLP. CD127 is a 65-75 kDa type-I transmembrane protein that belongs to the hematopoietin receptor and the Ig gene superfamilies. Mice lacking CD127 display profoundly impaired development of the B and T lymphoid cell lineages, but display no obvious nonlymphoid abnormalities. CD127 is expressed on common lymphoid progenitors and early stages of B lineage development in the bone marrow, the earliest thymocyte progenitors, CD4-CD8- double-negative and CD4+ and CD8+ single-positive thymocytes, naοve and memory T lymphocytes, γδ TCR + T cells, thymic NK cells, and bone marrow stromal cells. CD127 is downregulated upon activation of naοve T cells and CD127 re-expression identifies effector cells that subsequently differentiate into memory T cells. The A7R34 antibody blocks IL-7 binding to CD127. This antibody has been used in both in vitro and in vivo studies to define the biological roles played by CD127. |
| 别名 | Interleukin-7 receptor alpha chain; IL-7R alpha; IL7RA; IL-7RA; IL-7Rα; Il7 |
| 同种亚型 | Rat WI, also known as Wistar (outbred) IgG2a< |
| 反应种属 | Mouse (QC Testing) |
性能| 供应商 | BD Pharmingen |
| 免疫原 | Mouse |
| 存放说明 | Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.The antibody was conjugated with BD Horizon™ BV421 under optimum conditions, and unconjugated antibody and free BD Horizon™ BV421 were removed.
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| 存储溶液 | Aqueous buffered solution containing BSA and ≤0.09% sodium azide. |
| 浓度 | 0.2 mg/ml |
