Ms Notch2 PE 16F11 100ug
货号：
562755 基本售价：
4085.0 元 规格：
100ug
产品信息
概述| 货号 | 562755 |
| 描述 | The 16F11 monoclonal antibody specifically binds to the extracellular domain of Notch2. This Type 1 transmembrane protein is a member of the Notch family that includes Notch1-4. Notch ligands include membrane-bound Jagged1, Jagged2 and Delta-like1, 3 and 4. Notch receptors mediate juxtacrine signals between adjacent cells. Upon ligand binding, Notch2 undergoes proteolytic cleavage that results in the release of the Notch intracellular domain, NICD. NICD translocates to the nucleus where it forms a transcriptional activator complex with the RBP-J DNA binding factor and other transcriptional cofactors. These multimeric complexes regulate the expression of multiple genes including those that orchestrate many facets of embryonic development and the subsequent functioning of cells within multiple organ systems. Notch2 is expressed on bone marrow cells, DN1 and DN2 thymocytes, B cells and activated T cells. Notch2 plays multiple roles in the immune system including the development of marginal zone B cells and the regulation of granzyme B expression by CD8+ T cells. In altered forms, Notch2 has been implicated in cellular transformation or progression in various neoplasms. |
| 别名 | Notch2; Notch 2; NOTC2; Motch B; N2 |
| 同种亚型 | Rat IgG1, κ |
| 反应种属 | Mouse (QC Testing) |
性能| 供应商 | BD Pharmingen |
| 免疫原 | Mouse Notch2 extracellular domain Recombinant Protein |
| 标记 | PE |
| 存放说明 | The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.The antibody was conjugated with R-PE under optimum conditions, and unconjugated antibody and free PE were removed.Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
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| 存储溶液 | Aqueous buffered solution containing ≤0.09% sodium azide. |
| 浓度 | 0.2 mg/ml |
