Ms CD11b APC M1/70 100ug
货号：
553312 基本售价：
4050.0 元 规格：
100ug
产品信息
概述| 货号 | 553312 |
| 描述 | The M1/70 monoclonal antibody specifically binds to CD11b, also known as Integrin alpha M (Itgam or αM). CD11b is a 170-kDa type 1 transmembrane glycoprotein and belongs to the Integrin alpha chain family. CD11b serves as the alpha chain of the heterodimeric Mac-1 integrin (CD11b/CD18, αMβ2), also known as complement receptor 3 (CR3). Mac-1 mediates adhesion to ICAM-1 (CD54), ICAM-2 (CD102), fibrinogen and binding to C3bi. Mac-1 is expressed at varying levels on granulocytes, macrophages, myeloid-derived dendritic cells, natural killer cells, microglia, and B-1 B lymphocytes. Mac-1 expression is rapidly up-regulated on neutrophils after activation, in the same time period that CD62L (L-selectin) is shed from the cell surface. The M1/70 antibody reportedly blocks cell adherence and C3bi binding but does not block cell-mediated lysis. Cross-reaction of the M1/70 antibody with CD11b expressed on human monocytes, polymorphonuclear leukocytes, and NK cells has been reported. |
| 别名 | Itgam; Integrin alpha-M; Ly-40; Mac-1a; Mac-1 alpha; CR3A; CR-3 alpha chain |
| 同种亚型 | IgG2b,κ |
| 反应种属 | Mouse (QC Testing) Human (Reported) |
| 来源宿主 | Rat |
| 使用方法 | FC |
性能| 供应商 | BD Pharmingen |
| 免疫原 | Mouse Splenic Cells |
| 标记 | APC |
| 存放说明 | Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.The antibody was conjugated to APC under optimum conditions, and unconjugated antibody and free APC were removed.
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| 存储溶液 | Aqueous buffered solution containing protein stabilizer and ≤0.09% sodium azide. |
| 浓度 | 0.2 mg/ml |
