MST1 Pure 7/MST1 50ug
货号：
611052 基本售价：
3726.0 元 规格：
50ug
产品信息
概述| 货号 | 611052 |
| 描述 | Ste20 is a S. cerevisiae Ser/Thr protein kinase that functions upstream of the MAP kinase module. Mammalian and yeast homologs of this kinase are divided into two classes based on their structure and regulation. Members of the first class (Ste20, Cla4, and p21-activated protein kinase [PAK]) contain a C-terminal kinase domain, an N-terminal regulatory domain and a small GTPase Rac1/Cdc42-binding domain. Members of the second class lack GTPase-binding sites, but are similar to the former class throughout the catalytic domain. The latter class includes GC kinase, HPK, KHS, KRS1 & 2, MST1, 2, & 3, and SOK-1. MST1 (Mammalian Sterile Twenty-like-1) is a ubiquitously expressed kinase that contains an N-terminal kinase domain and C-terminal dimerization and inhibitory domains. Apoptotic stimuli, such as anti-Fas, result in cleavage of the C-terminal regulatory domain by caspase-3 or a related caspase, and activation of MST1. Overexpression of MST1 induces caspase activity, apoptotic morphological changes, and the activation of the SAPK and p38 MAPK pathways. Thus, MST1 is thought to function as a component of a positive feedback loop that amplifies the apoptotic response. |
| 别名 | Mammalian Sterile Twenty-like 1; Mammalian STE20-like kinase-1 |
| 同种亚型 | IgG1 |
| 反应种属 | Human (QC Testing) |
| 来源宿主 | Mouse |
| 使用方法 | WB, IF |
性能| 供应商 | BD Pharmingen |
| 免疫原 | Human MST1 aa. 331-483 |
| 存放说明 | The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.Store undiluted at -20°C.
|
| 存储溶液 | Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide. |
| 浓度 | 250 µg/ml |
