Ms CD212 PE 114 100ug
货号：
551974 基本售价：
3696.0 元 规格：
100ug
产品信息
概述| 货号 | 551974 |
| 描述 | The 114 monoclonal antibody specifically binds to mouse CD212 (the β 1 subunit of IL-12R β 1), originally termed IL-12R β , of the mouse IL-12 receptor complex. The IL-12R β 1 subunit associates with a β 2 subunit to form a heterodimeric IL-12 receptor complex. Each one of the IL-12R subunits exhibits low affinity for IL-12, but in combination, they bind IL-12 with high affinity. The IL-12R β 1 subunit interacts primarily with IL-12 p40 whereas the IL-12R β 2 binds both to IL-12 p40 and IL-12 p35. IL-12R β 1 is required for high affinity binding of IL-12 but IL-12R β 2 is required for signaling. IL-12R β 1 has more recently been described to bind IL-23, a heterodimer formed of the p40 subunit from IL-12, and p19. The cytoplasmic regions of the β 1 and β 2 subunits contain the box1 and box2 motifs found in other cytokine receptors such as gp130, LIFR and G-CSFR. IL-12R β 1 are primarily expressed by activated T cells and NK cells. Experiments with IL-12R β 1 deficient mice have shown that IL-12R β 1 is necessary for mouse T and NK cell responsiveness to IL-12 p75. The 114 antibody was generated by immunizing IL-12R β 1 deficient mice of (129 x BALB/c)F1 background with mouse Ba/F3 cells that were stably transfected with IL-12R β1. |
| 别名 | Il12rb1; IL-12R-beta-1; IL-12 Receptor β1 chain |
| 同种亚型 | IgG2a,κ |
| 反应种属 | Mouse (QC Testing) |
| 来源宿主 | Mouse |
| 使用方法 | FC |
性能| 供应商 | BD Pharmingen |
| 免疫原 | IL-12Rβ1 Transfected Cell Line |
| 标记 | PE |
| 存放说明 | The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.The antibody was conjugated with R-PE under optimum conditions, and unconjugated antibody and free PE were removed.Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
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| 存储溶液 | Aqueous buffered solution containing ≤0.09% sodium azide. |
| 浓度 | 0.2 mg/ml |
