Ms VGma 3 TCR FITC 536 250ug
货号：
553229 基本售价：
3630.0 元 规格：
250ug
产品信息
概述| 货号 | 553229 |
| 描述 | The 536 antibody reacts with V γ 3† T-cell Receptor (TCR)-bearing T lymphocytes, which are the predominant γδ TCRbearing cells in the early fetal thymus and the adult epidermis of euthymic mice. The first T cells to mature in the embryonic thymus express the V γ 3 and V δ 1 TCR chains, and their development is dependent upon IL-7. There is evidence that the V γ 3 TCR-bearing fetal thymocytes are the precursors of the majority of dendritic epidermal T cells (DEC), which may be replenished in the adult by proliferation in situ rather than by seeding from primary lymphoid organs. Although the V γ 3 TCR is almost exclusively found in the DEC population, it has been shown that the homing of DEC to the epidermis does not require expression of the V γ 3 gene segment. V γ 3 TCR-bearing dermal dendritic cells have also been described. V γ 3 TCR has also been found on a subset of T lymphocytes in the lactating mammary gland and on T lymphocytes accumulating at the site of antigenic challenge in contact-sensitized mice. Plate-bound 536 antibody activates V γ 3 TCR-bearing T cells, and Fab fragments of mAb 536 block in vitro stimulation of DEC by keratinocytes. †Please note that the V γ 3 designation correlates with the nomenclature of Garman, Doherty, and Raulet; the V γ 5 designation of Heilig and Tonegawa is equivalent. |
| 同种亚型 | IgG1,κ |
| 反应种属 | Mouse (QC Testing) |
| 来源宿主 | Syr hamster |
| 使用方法 | FC |
性能| 供应商 | BD Pharmingen |
| 免疫原 | AKR mouse dendritic epidermal cell clone 7-17 |
| 标记 | FITC |
| 存放说明 | The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.The antibody was conjugated with FITC under optimum conditions, and unreacted FITC was removed.Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
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| 存储溶液 | Aqueous buffered solution containing ≤0.09% sodium azide. |
| 浓度 | 0.5 mg/ml |
