Ms CD253 Pure N2B2 100ug
货号：
550320 基本售价：
3434.0 元 规格：
100ug
产品信息
概述| 货号 | 550320 |
| 描述 | The N2B2 antibody reacts with mouse TRAIL (TNF-Related Apoptosis-Inducing Ligand, also known as APO-2 ligand or Ly-81), a 40-kDa type-II transmembrane protein of the TNF family. This antibody recognizes mouse Trail -transfected 2PK-3 cells, but not the parental cell line. TRAIL selectively induces apoptosis in various transformed cells, but not in normal cells. Five receptors have been identified for human TRAIL, whereas only one receptor has been described for the mouse counterpart thus far. The pattern of expression of mouse TRAIL is controversial. TRAIL has been detected, with a rabbit polyclonal antibody, on the surface of activated CD4+ and CD8+ T lymphocytes, as well as on CD45R/B220+ lymphocytes, and transformed T- and B-cell lines. Similar results were obtained by western blot and mRNA analyses. However, these results could not be reproduced with the N2B2 mAb. TRAIL expression, detected with the N2B2 mAb, is induced on CD3- NK1.1+ cells after stimulation with IL-2 or IL-15. However, neither freshly isolated nor activated T cells showed TRAIL expression on the cell surface. Furthermore, TRAIL mediates NK-cell cytotoxicity, which is blocked by the N2B2 mAb. TRAIL has been renamed as CD253 recently. |
| 别名 | TRAIL, APO-2L, Ly-81, TL2 |
| 同种亚型 | IgG2a,κ |
| 反应种属 | Mouse (QC Testing) |
| 来源宿主 | Rat |
| 使用方法 | FC |
性能| 供应商 | BD Pharmingen |
| 免疫原 | Mouse Trail-transfected 2PK-3 cells |
| 存放说明 | The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.Store undiluted at 4°C.
|
| 存储溶液 | Aqueous buffered solution containing ≤0.09% sodium azide. |
| 浓度 | 0.5 mg/ml |
