Ms CD279 APC J43 50ug
货号：
562671 基本售价：
3330.0 元 规格：
50ug
产品信息
概述| 货号 | 562671 |
| 描述 | The J43 monoclonal antibody specifically binds to CD279 (PD-1), a 50-55-kDa glycoprotein encoded by the Pdcd1gene of the CD28 family of the Ig superfamily. The expression of Pdcd1mRNA and PD-1 protein is tightly regulated. PD-1 is transiently expressed on CD4-CD8thymocytes, it is upregulated on some cell lines upon induction of apoptosis, it is induced on thymocytes and splenic T and B lymphocytes after stimulation through their antigen receptors, and it is induced on activated myeloid cells. In addition, Pdcd1mRNA is transiently expressed in developing B lymphocytes at the pro-B-cell stage. The presence of an ITIM (ImmunoreceptorTyrosine-basedInhibitoryMotif) on PD-1s intracytoplasmic region and the development of splenomegaly and breakdown of peripheral tolerance in PD-1[-/-] mice suggest that PD-1 may be involved in the negative regulation of immune responses. The PD-1 ligands, B7-H1 (also known as PD-L1) and B7-DC (PD-L2), are members of the B7 family of the Ig superfamily. The J43 antibody blocks the binding of PD-1 to its two ligands. |
| 别名 | PD-1; Pdcd1; Pd1; Pdc1; Ly101; programmed cell death 1 |
| 同种亚型 | Armenian Hamster IgG2, κ |
| 反应种属 | Mouse (QC Testing) |
性能| 供应商 | BD Pharmingen |
| 免疫原 | Syrian Hamster kidney cell line BKH transfected with Pdcd1 cDNA |
| 标记 | APC |
| 存放说明 | Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.The antibody was conjugated to APC under optimum conditions, and unconjugated antibody and free APC were removed.
|
| 存储溶液 | Aqueous buffered solution containing ≤0.09% sodium azide. |
| 浓度 | 0.2 mg/ml |
