Ms CD11a IHC Pure M17/4 1mL
货号：
550528 基本售价：
3192.0 元 规格：
1mL
产品信息
概述| 货号 | 550528 |
| 描述 | The M17/4 antibody reacts with the 180 kDa α L chain of LFA-1 (CD11a/CD18, αLβ 2 integrin), a heterodimeric surface glycoprotein expressed on almost all leukocytes. CD8a+CD8b- intestinal intraepithelial T lymphocytes, which are believed to be thymus independent, do not express CD11a. LFA-1 mediates a variety of heterotypic and homotypic intercellular adhesions through interaction with ICAM-1 (CD54) and ICAM-2 (CD102), including participation in the immunological synapses between CD8+ T lymphocytes and antigen-presenting cells. mAb M17/4 blocks a variety of LFA-1-mediated cells interactions in vitro, and costimulatory effects have also been described. In vivo treatment with M17/4 mAb reduces the severity of graft-versus-host reactions, prolongs allograft survival, inhibits the development of autoimmunity, and blocks substance P-induced leukocyte migration. The M17/4 and 2D7 (Cat. No. 553120) antibodies are reported to recognize different epitopes of the CD11a molecule. |
| 别名 | Itgal; Integrin alpha-L; Integrin αL; ITAL; LFA-1A; LFA-1α; Ly-15 |
| 同种亚型 | IgG2a,κ |
| 反应种属 | Mouse (QC Testing) |
| 来源宿主 | Rat |
| 使用方法 | IHC(Fr) |
性能| 供应商 | BD Pharmingen |
| 免疫原 | C57BL/6 Mouse Splenic Secondary Cytotoxic T Lymphocytes |
| 存放说明 | Store undiluted at 4°C.The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
|
| 存储溶液 | Aqueous buffered solution containing BSA, goat serum, and ≤0.09% sodium azide. |
| 浓度 | 31.25 µg/ml |
