Ms GRAIL Pure H11-744 100ug
货号：
557799 基本售价：
3152.0 元 规格：
100ug
产品信息
概述| 货号 | 557799 |
| 描述 | The H11-744 antibody reacts with GRAIL ( GeneR elated to AnergyInL ymphocytes protein), a 428-amino acid glycoprotein with an apparent molecular weight of 62-66 kDa that is preferentially expressed in anergized CD4-positive CD25-negative T lymphocytes. The GRAIL protein sequence is homologous to several zinc RING finger-containing proteins, and thus, its gene has been designated Rnf128 (RING finger protein 128). Rnf128 transcripts are found in several mouse organs (including ovary, kidney, liver, brain, and heart), and transcription is induced rapidly (within 4 hours) in CD4-positive T cells upon in vitro induction of anergy. The expression of GRAIL correlates with the inhibition of IL-2 production in in vitro -anergized CD4-positive CD25-negative T cells, and GRAIL expression reduces IL-2 and IL-4 production in T-cell hybridomas activated by plate-bound anti-CD3 plus anti-CD28. GRAIL protein is localized in the recycling endosomal compartment, functions as an E3 ubiquitin ligase, and is required for anergy induction of CD4-positive T cells in vivo . |
| 别名 | Goliath-related E3 ubiquitin-protein ligase 1, RNF128 |
| 同种亚型 | Rat LOU, also known as Louvain, LOU/C, LOU/M IgG |
| 反应种属 | Mouse (QC Testing) |
性能| 供应商 | BD Pharmingen |
| 免疫原 | Mouse GRAIL (full-length) Recombinant Protein |
| 存放说明 | The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.Store undiluted at 4°C.
|
| 存储溶液 | Aqueous buffered solution containing ≤0.09% sodium azide. |
| 浓度 | 0.5 mg/ml |
