Ms CD25 BV421 3C7 25ug
货号：
566228 基本售价：
3100.0 元 规格：
25UG
产品信息
概述| 货号 | 566228 |
| 描述 | The 3C7 monoclo nal antibody specifically binds to CD25, the low affinity IL-2 Receptor (IL-2Rα, p55) expressed on activated T and B lymphocytes from all mouse strains tested. IL-2Rα by itself is not a signaling receptor. However, it can combine with IL-2 Receptor β (CD122) and γc (CD132) chains to form high-affinity, signaling receptor complexes for IL-2. Resting T and B lymphocytes and resting and activated NK cells do not express IL-2Rα. CD25 is transiently expressed at a low level during normal B-cell development in th e bone marrow on the CD45R/B220low TdT- sIg- Pre-B/Pre-B-II and CD45R/B220low TdT- sIgM+ sIgD- immature B stages, but not on the CD45R/B220low TdT+ sIg- Pro-B/Pre B-I stage nor on CD45R/B220high TdTsIgM+ sIgD+ mature B cells. It is expressed at a higher level during a very early stage of T-cell development in fetal and adult thymus. Peripheral CD25+ CD4+ T lymphocytes called regulatory T (Treg) cells are involved in the maintenance of self-tolerance. It has also been reported that dendritic cells express CD25, recognized by mAb 7D4, another CD25-specific antibody. The 3C7 antibody recognizes an epitope of CD25 which is distinct from those recognized by other CD25-specific mAbs, 7D4 and PC61. 3C7 blocks the binding of IL-2 to CD25. |
| 别名 | Interleukin-2 receptor alpha chain; IL-2RA; IL-2Rα; Il2ra; IL-2R p55 |
| 同种亚型 | Rat LEW, also known as Lewis IgG2b, κ |
| 反应种属 | Mouse (QC Testing) |
性能| 供应商 | BD Pharmingen |
| 免疫原 | IL-2-dependent BALB/c mouse cell line |
| 存放说明 | Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.The antibody was conjugated with BD Horizon™ BV421 under optimum conditions, and unconjugated antibody and free BD Horizon™ BV421 were removed.
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| 存储溶液 | Aqueous buffered solution containing BSA and ≤0.09% sodium azide. |
| 浓度 | 0.2 mg/ml |
