Ms IL-12 Rcptr Bta2 Pure HAM10B9 100ug
货号：
552819 基本售价：
2600.0 元 规格：
100ug
产品信息
概述| 货号 | 552819 |
| 描述 | The HAM10B9 antibody reacts with the β 2subunit (IL-12R β 2), of the mouse IL-12 receptor complex. The IL-12R β 2 subunit associates with a β 1 subunit to form a heterodimeric IL-12 receptor complex. Each one of the IL-12R subunits exhibits low affinity for IL-12, but in combination, they bind IL-12 with high affinity. The IL-12R β 1 subunit interacts primarily with IL-12 p40 whereas the IL-12R β 2 binds both to IL-12 p40 and IL-12 p35. IL-12R β 1 is required for high affinity binding of IL-12 but IL-12R β 2 is required for signaling. The cytoplasmic regions of the β 1 and β 2 subunits contain the box 1 and box 2 motifs found in other cytokine receptors such as gp130, LIFR and G-CSFR. Naive T cells do not express IL-12R but both IL-12R subunits can be induced on T cells by antigenic stimulation. The IL12R is also expressed on activated NK cells. Th1 cells express both IL-12R subunits while Th2 cells lose the β 2 subunit during differentiation. The HAM10B9 antibody was generated by immunizing hamsters with mouse IL-12R β 2 transfectants. |
| 同种亚型 | IgG1,κ |
| 反应种属 | Mouse (QC Testing) |
| 来源宿主 | Ar hamster |
| 使用方法 | FC |
性能| 供应商 | BD Pharmingen |
| 免疫原 | Mouse IL-12Rβ2 transfectants |
| 存放说明 | The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.Store undiluted at 4°C.
|
| 存储溶液 | Aqueous buffered solution containing ≤0.09% sodium azide. |
| 浓度 | 0.5 mg/ml |
