Ms CD45RB BV421 16A 25ug
货号：
565993 基本售价：
2480.0 元 规格：
25ug
产品信息
概述| 货号 | 565993 |
| 描述 | The 16A antibody reacts with an exon B-dependent epitope of CD45 lycoprotein, which is found at high density on peripheral B cells, T cytotoxic/suppressor cells,subset of T helper cells, and most thymocytes and at low density on macrophages and dendritic cells.The level of CD45RB expressionappears to decrease as T lymphocytes progress from naive to memory cells. In addition, subpopulations of CD4+ T cells which express high and low levels ofD45RB have differentytokine secretion profiles and mediate distinct immunological functions. CD25+D4+ regulatory T (Treg) lymphocytes which control intestinal inflammation and autoimmunity express low levels ofD45RB. CD45 is a member of the Protein Tyrosine Phosphatase (PTP) family: Its intracellular (COOH-terminal) region contains two PTP catalytic domains, and the extracellular region is highly variable due to alternative splicing of exons (designated A, B, and C, respectively), plus differing levels of glycosylation. The CD45 isoforms detected in the mouse are cell type-, maturation-, and activation state-specific. The CD45 isoforms play complex roles in T-cell and B-cell antigen receptor signal transduction. |
| 别名 | Ptprc; CD45R; CD45; LCA; Leukocyte common antigen; Ly-5; Lyt-4 |
| 同种亚型 | Rat IgG2a, κ |
| 反应种属 | Mouse (QC Testing) |
性能| 供应商 | BD Pharmingen |
| 免疫原 | Cloned Mouse TH2 cell lines |
| 标记 | BV421 |
| 存放说明 | Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.The antibody was conjugated with BD Horizon™ BV421 under optimum conditions, and unconjugated antibody and free BD Horizon™ BV421 were removed.
|
| 存储溶液 | Aqueous buffered solution containing BSA and ≤0.09% sodium azide. |
| 浓度 | 0.2 mg/ml |
