MS CD279 BV421 J43 25UG
货号：
565942 基本售价：
2480.0 元 规格：
25ug
产品信息
概述| 货号 | 565942 |
| 描述 | The J43 monoclonal antibody specifically binds to CD279 (PD-1), a 50-55-kDa glycoprotein encoded by the Pdcd1gene of the CD28 family of the Ig superfamily. The expression of Pdcd1mRNA and PD-1 protein is tightly regulated. PD-1 is transiently expressed on CD4-CD8thymocytes, it is upregulated on some cell lines upon induction of apoptosis, it is induced on thymocytes and splenic T and B lymphocytes after stimulation through their antigen receptors, and it is induced on activated myeloid cells. In addition, Pdcd1mRNA is transiently expressed in developing B lymphocytes at the pro-B-cell stage. The presence of an ITIM (ImmunoreceptorTyrosine-basedInhibitoryMotif) on PD-1s intracytoplasmic region and the development of splenomegaly and breakdown of peripheral tolerance in PD-1[-/-] mice suggest that PD-1 may be involved in the negative regulation of immune responses. The PD-1 ligands, B7-H1 (also known as PD-L1) and B7-DC (PD-L2), are members of the B7 family of the Ig superfamily. The J43 antibody blocks the binding of PD-1 to its two ligands. |
| 别名 | PD-1; Pdcd1; Pd1; Pdc1; Ly101; programmed cell death 1 |
| 同种亚型 | Armenian Hamster IgG2, κ |
| 反应种属 | Mouse (QC Testing) |
性能| 供应商 | BD Pharmingen |
| 免疫原 | Syrian Hamster kidney cell line BKH transfected with Pdcd1 cDNA |
| 标记 | BV421 |
| 存放说明 | Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.The antibody was conjugated with BD Horizon™ BV421 under optimum conditions, and unconjugated antibody and free BD Horizon BV421 were removed.
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| 存储溶液 | Aqueous buffered solution containing BSA and ≤0.09% sodium azide. |
| 浓度 | 0.2 mg/ml |
