Ms KLRG1 Biotin 2F1 100ug
货号：
550863 基本售价：
2000.0 元 规格：
100ug
产品信息
概述| 货号 | 550863 |
| 描述 | The 2F1 monoclonal antibody specifically binds to KLRG1 ( K iller cell Lectin-likeReceptorG1 ), which is the mouse homologue of the rat mast cell function-associated antigen (MAFA), on all mouse strains tested (eg, AKR/J, BALB/c, C3H/HeN, C3H.SW, C57BL/6, DBA/1, SJL, 129/J). Unlike rat MAFA, which is expressed on mast cells, mouse KLRG1 is expressed on a large subset of NK cells, lymphokine-activated killer (LAK) cells, adherent LAK (A-LAK) cells, subsets of activated CD8+ T lymphocytes, and small fractions of CD4+ and CD8+ T cells, but not mast cells. The expression of KLRG1 is correlated with reduced proliferative capacity of activated T lymphocytes or reduced effector functions of activated NK cells. This molecule is believed to play a common role in the regulation of leukocytes of both the innate and adaptive immune system. It has been observed that the 2F1 mAb stains the rat basophilic leukemia cell line, RBL-2H3, which is known to express MAFA. The KLRG1 protein is an inhibitory lectin-like type II transmembrane receptor containing a cytoplasmic motif similar to ITIM ( ImmunoreceptorTyrosine-basedInhibitoryM otif); its ligand has not been identified KLRG1 is expressed mainly as a homodimeric molecule consisting of two N-glycosylated subunits of approximately 30-38 kDa. The level of KLRG1 expression is reduced in MHC class I-deficient mice, although direct binding of KLRG1 to MHC class I antigens could not be detected. Cross-linking of KLRG1 by 2F1 mAb reduces TCR-mediated Ca++ mobilization and cytotoxic responses (but not IFN- γ production) by CD8+ T cells and inhibits IFN- γ and TNF- α production and redirected lysis by NK cells. |
| 别名 | Klrg1; Killer cell lectin-like receptor subfamily G member 1; MAFA |
| 同种亚型 | IgG2,κ |
| 反应种属 | Mouse (QC Testing) Rat (Tested in Development) |
| 来源宿主 | Syr hamster |
| 使用方法 | FC |
性能| 供应商 | BD Pharmingen |
| 免疫原 | A-LAK from C57BL/6 mice |
| 标记 | Biotin |
| 存放说明 | Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.The antibody was conjugated with biotin under optimum conditions, and unreacted biotin was removed.
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| 存储溶液 | Aqueous buffered solution containing ≤0.09% sodium azide. |
| 浓度 | 0.5 mg/ml |
