Human DKK-1, research grade (2 µg)
货号：
130-103-443 基本售价：
询价 规格：
2 μg
产品信息
概述| 货号 | 130-103-443 |
| 描述 | DKK-1 stands for Dickkopf-1 related protein. Human DKK-1 is a recombinant protein optimized for use in cell culture, differentiation studies, and functional assays. |
性能| 供应商 | Miltenyi |
| 背景 | Dickkopf-1 related protein (DKK-1) is a member of the DKK family, which also includes DKK-2, DKK-3 and DKK-4. It was initially identified as an important embryogenic factor, especially for the development of the head. DKK-1 effects are mainly due to its role as negative regulator of Wnt signally pathway, by forming complexes with LDL-receptor-related protein 6. High expression of DKK-1 has been found during mesenchymal development, and is crucial for limbs and bones modeling, but also cardiogenesis. TNF-α plays a central role in DKK-1 induction, during arthritis, and blood levels of DKK-1 increase during multiple myeloma. DKK-1 acts also as negative regulator of neuronal survival and neural crest formation. |
