| 货号 | 3119/500U |
| 是否允许进口 | 否 |
| 是否危险品 | 是 |
| 供应商 | Tocris |
| 生物活性 | Nicotinic receptor antagonist that displays selectivity for homomeric α7 and α9 receptors (IC50 values are 220 and 1800 nM respectively). Displays no effect on α2β2,α3β2,α4β2,α2β4,α3β3 and α4β4 subunit combinations. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 计算分子量 | 1351.6 |
| 分子式 | C52H78N20O15 |
| 可溶性/溶解性 | Soluble to 1 mg/ml in 20% acetonitrile / water |
| 序列号 | GCCSDPRCAWRC (Modifications: Cys-12 = C-terminal amide, Disulfide bridge between 2 - 8, 3 - 12) |
| 参考文献 | Pereiraet al (1996) α-Conotoxin-ImI: a competitive antagonist at α-Bungarotoxin-sensitive neuronal nicotinic receptors in hippocampal neurons. J.Pharmacol.Exp.Ther. 278 1472. PMID: 8819535. Johnsonet al (1995) α-Conotoxin ImI exhibits subtype-specific nicotinic acetylcholine receptor blockade: preferential inhibition of homomeric α7 and α9 receptors. Mol.Pharmacol. 48 194. PMID: 7651351. McIntoshet al (1994) A nicotinic acetylcholine receptor ligand of unique specificity, α-conotoxin ImI. J.Biol.Chem. 269 16733. PMID: 8206995. |