| 货号 | 1340/500U |
| 是否允许进口 | 否 |
| 是否危险品 | 是 |
| 供应商 | Tocris |
| 生物活性 | Highly potent and selective competitive antagonist for α3β2 subunit-containing nicotinic receptors (IC50 = 0.5 - 3.5 nM at α3β2 expressed in Xenopus oocytes). Also potently blocks β3-containing neuronal nicotinic receptors. Displays > 200-fold selectivity for α3β2 over α2β2,α4β2 and α3β4. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 计算分子量 | 1710.99 |
| 分子式 | C67H103N23O2 |
| 可溶性/溶解性 | Soluble to 1 mg/ml in water |
| 序列号 | GCCSNPVCHLEHSNLC (Modifications: Disulfide bridge between 2 - 8, 3 - 16, Cys-16 = C-terminal amide) |
| 参考文献 | Davidet al (2010) Biochemical and functional properties of distinct nicotinic acetylcholine receptors in the superior cervical ganglion of mice with targeted deletions of nAChR subunit genes. Eur.J.Neurosci. 31 978. PMID: 20377613. McIntoshet al(2000)Conus peptides: novel probes for nicotinic acetylcholine receptor structure and function. Eur.J.Pharmacol. 393 205. PMID: 10771014. Harveyet al (1997) Determinants of specificity for α-conotoxin MII on α3β2 neuronal nicotinic receptors. Mol.Pharmacol. 51 336. PMID: 9203640. Cartieret al (1996) A new α-conotoxin which targets α3β2 nicotinic acetylcholine receptors. J.Biol.Chem. 271 7522. PMID: 8631783. |