| 货号 | 1085/250U |
| 是否允许进口 | 否 |
| 是否危险品 | 是 |
| 供应商 | Tocris |
| 生物活性 | Peptide neurotoxin; selectively and reversibly blocks N-type calcium channels (IC50 = 0.15 nM). Reduces (RS)-3,5-DHPG (Cat. No. 0342)-induced long term depression in vivo. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 计算分子量 | 3037 |
| 分子式 | C120H182N38O |
| 可溶性/溶解性 | Soluble to 1 mg/ml in water |
| 序列号 | CKSXGSSCSXTSYNCCRSCNXYTKRCY (Modifications: X = Hyp, Disulfide bridge between 1 - 16, 8 - 19, 15 - 26, Tyr-27 = C-terminal amide) |
| 参考文献 | Connellyet al (2011) Distinct mechanisms contribute to agonist and synaptically induced metabotropic glutamate receptor long-term depression. Eur.J.Pharmacol. 667 160. PMID: 21575629. Wright and Angu (1997) Prolonged cardiovascular effects of the N-type Ca2+ channel antagonist ω-conotoxin GVIA in conscious rabbits. J.Cardiovasc.Pharmacol. 30 392. PMID: 9300325. Satoet al (1993) Role of basic residues for the binding of omega-conotoxin GVIA to N-type calcium channels. Biochem.Biophys.Res.Comm. 194 1292. PMID: 8394704. Tsienet al (1988) Multiple types of neuronal calcium channels and their selective modulation. TiNS 11 431. PMID: 2469160. |