| 货号 | 3996/50 |
| 别名 | 2-[(8-Chlorodibenzo(Z)[b,f]thiepin- |
| 是否允许进口 | 否 |
| 是否危险品 | 是 |
| 供应商 | Tocris |
| 生物活性 | 5-HT2A receptor and dopamine D2 receptor antagonist (Ki values are 0.69 and 2.3 nM respectively). Also a potent histamine H1 receptor antagonist (IC50 = 8.0 nM). Atypical antipsychotic; exhibits antidepressive and anxiolytic effects in vivo. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >99 % |
| 计算分子量 | 331.86 |
| 分子式 | C18H18ClNOS |
| 可溶性/溶解性 | Soluble to 50 mM in DMSO |
| 参考文献 | Shoboet al (2010) Norzotepine, a major metabolite of zotepine, exerts atypical antipsychotic-like and antidepressant-like actions through its potent inhibition of norepinephrine reuptake. J.Pharmacol.Exp.Ther. 333 772. PMID: 20223878. Yamamuraet al (2009) Effects of zotepine on extracellular levels of monamine, GABA and glutamate in rat prefrontal cortex. Br.J.Pharmacol. 157 656. PMID: 19371334. Herrick-Daviset al (2000) Inverse agonist activity of atypical antipsychotic drugs at human 5-hydroxytryptamine2C receptors. J.Pharmacol.Exp.Ther. 295 226. PMID: 10991983. |