| 货号 | 2799/10U |
| 别名 | ω-Aga-IV A |
| 是否允许进口 | 否 |
| 是否危险品 | 是 |
| 供应商 | Tocris |
| 生物活性 | Selective blocker of P-type calcium channels (IC50 < 1 - 3 nM). Also inhibits N-type channels at micromolar concentrations. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 计算分子量 | 5202.25 |
| 分子式 | C217H360N68O |
| 可溶性/溶解性 | Soluble in water |
| 序列号 | KKKCIAKDYGRCKWGGTPCCRGRGCICSIM (Modifications: Disulfide bridge between 4 - 20, 12 - 25, 19 - 36, 27 - 34) |
| 参考文献 | Tringhamet al (2008) Protease treatment of cerebellar purkinje cells renders ω-agatoxin IVA-sensitive Ca2+ channels insensitive to inhibition by ω-conotoxin GVIA. J.Pharmacol.Exp.Ther. 324 806. PMID: 17975010. Bourinetet al (1999) Splicing of α1A subunit gene generates phenotypic variants of P- and Q-type calcium channels. Nat.Neurosci. 2 407. PMID: 10321243. Mintzet al (1992) P-type calcium channels blocked by the spider toxin ω-Aga-IVA. Nature 355 827. PMID: 1311418. Turneret al (1992) Calcium channels coupled to glutamate release identified by ω-Aga-IVA. Science 258 310. PMID: 1357749. |