| 货号 | 5042/100U |
| 别名 | PcTx1 |
| 是否允许进口 | 否 |
| 是否危险品 | 是 |
| 供应商 | Tocris |
| 生物活性 | Potent and selective acid-sensing ion channel 1a (ASIC1a) blocker (IC50 = 0.9 nM). Displays no effect at ASIC1b, ASIC2a, ASIC3, heteromeric ASIC channels, ENaC and KV2.1/2.2/4.2/4.3 channels expressed in oocytes, at concentrations up to 100 nM. Displays potent analgesic properties against thermal, mechanical, chemical, inflammatory and neuropathic pain in rodents. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 计算分子量 | 4689.41 |
| 分子式 | C200H312N62O |
| 可溶性/溶解性 | Soluble to 2 mg/ml in water |
| 序列号 | EDCIPKWKGCVNRHGDCCEGLECWKRRRSF (Modifications: Disulfide bridge: 3-18, 10-23, 17-33) |
| 参考文献 | Mazzucaet al (2007) A tarantula peptide against pain via ASIC1a channels and opioid mechanisms. Nat.Neurosci. 10 943. PMID: 17632507. Salinaset al (2006) The receptor site of the spider toxin PcTx1 on the proton-gated cation channel ASIC1a. J.Physiol. 570 339. PMID: 16284080. Escoubaset al (2003) Recombinant production and solution structure of PcTx1, the specific peptide inhibitor of ASIC1a proton-gated cation channels. Protein Sci. 12 1332. PMID: 12824480. Escoubaset al (2000) Isolation of a tarantula toxin specific for a class of proton-gated Na+ channels. J.Biol.Chem. 275 25116. PMID: 10829030. |