| 货号 | 2770/1 |
| 别名 | N-[trans-4-[2-(6-Cyano-3,4-dihydro- |
| 是否允许进口 | 否 |
| 是否危险品 | 是 |
| 供应商 | Tocris |
| 生物活性 | Selective dopamine D3 receptor antagonist (pKi values are 8.0, 6.0, 5.0 and <5.2 for D3, D2, 5-HT1D and 5-HT1B respectively). Brain penetrant. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >98 % |
| 计算分子量 | 511.49 |
| 分子式 | C28H30N4O.2HCl |
| 可溶性/溶解性 | Soluble to 5 mM in water and to 50 mM in DMSO |
| 参考文献 | Reavillet al (2000) Pharmacological actions of a novel, high-affinity, and selective human dopamine D3 receptor antagonist, SB-277011-A. J.Pharmacol.Exp.Ther. 294 1154. PMID: 10945872. Stempet al (2000) Design and synthesis of trans-N-[4-[2-(6-cyano-1,2,3,4-tetrahydroisoquinolin-2-yl)ethyl]cyclohexyl]-4-quinolinecarboxamide (SB-277011): a potent and selective dopamine D3 receptor antagonist with high oral bioavailability and CNS penetration in the rat. J.Med.Chem. 43 1878. PMID: 10794704. |