| 货号 | 1136/25U |
| 别名 | 9,10-Deepithio-9,10-didehydroacanth |
| 是否允许进口 | 否 |
| 是否危险品 | 是 |
| 供应商 | Tocris |
| 生物活性 | Potent inhibitor of protein phosphatase 1 (IC50 = 3 nM) and protein phosphatase 2A (IC50 = 0.2-1 nM). Displays > 100,000,000-fold selectivity over PP2B and PP2C. Tumor promoter. Shown to activate atypical protein kinase C in adipocytes. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 计算分子量 | 805.01 |
| 分子式 | C44H68O13 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| 参考文献 | McCluskeyet al (2002) Serine-threonine protein phosphatase inhibitors: development of therapeutic strategies. J.Med.Chem. 45 1151. PMID: 11881984. Standaertet al (1999) Okadaic acid activates atypical protein kinase C (ζ/λ) in rat and 3T3/L1 adipocytes. J.Biol.Chem. 274 14074. PMID: 10318822. Nuydenset al (1998) Okadaic acid-induced apoptosis in neuronal cells: evidence for an abortive mitotic attempt. J.Neurochem. 70 1124. PMID: 9489733. Cohenet al (1990) Okadaic acid: a new probe for the study of cellular regulation. TiBS 15 98. PMID: 2158158. Haysteadet al (1989) Effects of the tumour promotor okadaic acid on intracellular protein phosphorylation and metabolism. Nature 337 78. PMID: 2562908. Merck Index 126958. |