| 货号 | 1970/10 |
| 别名 | 2-Amino-2-(2-chlorophenyl)cyclohexa |
| 是否允许进口 | 否 |
| 是否危险品 | 是 |
| 供应商 | Tocris |
| 生物活性 | Major metabolite of ketamine that is a potent non-competitive NMDA receptor antagonist (Ki = 3.6 μM for displacement of [3H]-MK 801 in rat brain). Antinociceptive and anesthetic in vivo.R-enantiomer and S-enantiomer also available. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >99 % |
| 计算分子量 | 260.16 |
| 分子式 | C12H14ClNO.HCl |
| 可溶性/溶解性 | Soluble to 100 mM in water |
| CAS号 | 35211-10-0 |
| 参考文献 | Shimoyamaet al (1999) Oral ketamine is antinociceptive in the rat formalin test: role of the metabolite, norketamine. Pain 81 85. PMID: 10353496. Ebertet al (1997) Norketamine, the main metabolite of ketamine, is a non-competitive NMDA receptor antagonist in the rat cortex and spinal cord. Eur.J.Pharmacol. 333 99. PMID: 9311667. Leunget al (1986) Comparative pharmacology in the rat of ketamine and its two principal metabolites, norketamine and (Z)-6-hydroxynorketamine. J.Med.Chem. 29 2396. PMID: 3783598. |