| 货号 | 1814/5 |
| 别名 | 4-[3-[4-[Piperidinyl]but-1-ynyl]ben |
| 是否允许进口 | 否 |
| 是否危险品 | 是 |
| 供应商 | Tocris |
| 生物活性 | Histamine H3 receptor antagonist (pKi values are 8.15 and 8.93 for rat and human H3 receptors respectively). Increases extracellular norepinephrine and acetylcholine levels in rat frontal cortex but does not stimulate dopamine release. Brain penetrant. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 385.37 |
| 分子式 | C20H28N2O.2HCl |
| 可溶性/溶解性 | Soluble to 100 mM in water and to 25 mM in ethanol |
| 参考文献 | Boggset al (2009) JNJ-10181457, a selective non-imidazole histamine H3 receptor antagonist, normalizes acetylcholine neurotransmission and has efficacy in translational rat models of cognition. Neuropharmacology 56 1131. PMID: 19345233. Esbenshadeet al (2008) The histamine H3 receptor: an attractive target for the treatment of cognitive disorders. Br.J.Pharmacol. 154 1166. PMID: 18469850. Bonaventureet al (2007) Histamine H3 receptor antagonists: from target identification to drug leads. Biochem.Pharmacol. 73 1084. PMID: 17129577. |