| 货号 | 1230/100 |
| 别名 | N-[4-[[(2,4-Diamino-6-pteridinyl)me |
| 是否允许进口 | 否 |
| 是否危险品 | 是 |
| 供应商 | Tocris |
| 生物活性 | Cytotoxic agent. Inhibits thymidylate synthetase and de novo purine synthesis. Potent folic acid antagonist; inhibits dihydrofolate reductase. Also inhibits Ras carboxyl methylation in DKOB8 cells, leading to decreased p44 and Akt activation. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >99 % |
| 计算分子量 | 454.44 |
| 分子式 | C20H22N8O5 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| 参考文献 | Winter-Vannet al (2003) Targeting Ras signaling through inhibition of carboxyl methylation: an unexpected property of methotrexate. Proc.Natl.Acad.Sci.U.S.A. 100 6529. PMID: 12750467. Chuet al (1990) Mechanism of thymidylate synthase inhibition by methotrexate in human neoplastic cell lines and normal human myeloid progenitor cells. J.Biol.Chem. 265 8470. PMID: 2341391. Allegraet al (1987) Evidence for direct inhibition of de novo protein synthesis in human MCF-7 breast cells as a principal mode of metabolic inhibition by methotrexate. J.Biol.Chem. 262 13520. PMID: 2443493. Jolivetet al (1983) The pharmacology and clinical use of methotrexate. N.Engl.J.Med. 309 1094. PMID: 6353235. |