| 货号 | 3563/100U |
| 别名 | MgTX |
| 是否允许进口 | 否 |
| 是否危险品 | 是 |
| 供应商 | Tocris |
| 生物活性 | Potent KV1.3 channel blocker (IC50 = 36 pM). Displays no effect at calcium-activated channels. Reduces VEGF-induced transmembrane calcium influxes and nitric oxide production in human endothelial cells. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 计算分子量 | 4178.96 |
| 分子式 | C178H286N52O |
| 可溶性/溶解性 | Soluble to 0.50 mg/ml in water |
| 序列号 | TIINVKCTSPKQCLPPCKAQFGQSAGAKCM (Modifications: Disulfide bridge between 7 - 29, 13 - 34, 17 - 36) |
| 参考文献 | Erdoganet al (2005) Margatoxin inhibits VEGF-induced hyperpolarization, proliferation and nitric oxide production of human endothelial cells. J.Vasc.Res. 42 368. PMID: 16043967. Garcia-Calvoet al (1993) Purification, characterization, and biosynthesis of Margatoxin, a component of Centruroides margaritatus venom that selectively inhibits voltage-dependent potassium channels. J.Biol.Chem. 268 18866. PMID: 8360176. |