| 货号 | 3564/100U |
| 是否允许进口 | 否 |
| 是否危险品 | 是 |
| 供应商 | Tocris |
| 生物活性 | Potent blocker of voltage-sensitive K+ channels (IC50 values are 0.1, 1.1 and 25 nM for KV1.3, KV1.1 and KV1.2 channels) respectively). Also inhibits Ca2+-activated K+channels. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 计算分子量 | 4149.94 |
| 分子式 | C171H283N55O |
| 可溶性/溶解性 | Soluble to 2 mg/ml in water |
| 序列号 | GVEINVKCSGSPQCLKPCKDAGMRFGKCMN (Modifications: Disulfide bridge between 8 - 28, 14 - 33, 18 - 35) |
| 参考文献 | Korukottuet al (2008) High-resolution 3D structure determination of kaliotoxin by solid-state NMR spectroscopy. PLoS ONE 3 e2359. PMID: 18523586. Mourreet al (1999) Distribution in rat brain of binding sites of kaliotoxin, a blocker of Kv1.1and Kv1.3 α-subunits. J.Pharmacol.Exp.Ther. 291 943. PMID: 10565809. Romiet al (1993) Synthesis and characterization of kaliotoxin: is the 26-32 sequence essential for potassium channel recognition? J.Biol.Chem. 268 26302. PMID: 8253752. |