| 货号 | 4913/100U |
| 是否允许进口 | 否 |
| 是否危险品 | 是 |
| 供应商 | Tocris |
| 生物活性 | Selective blocker of NaV1.5 channels (IC50 = 348 nM); displays no effect on other isoforms, including NaV1.2, NaV1.4, NaV1.6 and NaV1.7. Thought to inhibit sodium channel activation by binding to the NaV1.5 S3-S4 linker of domain II. Selectively inhibits the activation of cardiac sodium channels, but has no effect on sodium channels in dorsal root ganglion neurons. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 分子式 | C174H241N47O |
| 可溶性/溶解性 | Soluble to 1 mg/ml in water |
| 序列号 | DGECGGFWWKCGRGKPPCCKGYACSKTWGW (Modifications: Disulfide bridge: 4-19,11-24,18-31) |
| 参考文献 | Ronget al (2011) Molecular basis of the tarantula toxin jingzhaotoxin-III (β-TRTX-Cj1α) interacting with voltage sensors in sodium channel subtype Nav1.5. FASEB J. 25 3177. PMID: 21665957. Xiaoet al (2004) Jingzhaotoxin-III, a novel spider toxin inhibiting activation of sodium channel in rat cardiac myocytes. J.Biol.Chem. 279 26220. PMID: 15084603. |