| 货号 | 1260/100 |
| 别名 | 22,23-Dihydroavermectin B1 |
| 是否允许进口 | 否 |
| 是否危险品 | 是 |
| 供应商 | Tocris |
| 生物活性 | Positive allosteric modulator of the α7 neuronal nicotinic acetylcholine receptor and the purinergic P2X4 receptor. Antihelmintic. Also modulates glutamate- and GABA-activated chloride channels. Potentiates glycine-gated currents at low concentrations (30 nM). |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >96 % |
| 计算分子量 | 875.1 |
| 分子式 | C48H74O14(B |
| 可溶性/溶解性 | Soluble to 50 mM in DMSO |
| 参考文献 | Shanet al (2001) Ivermectin, an unconventional agonist of the glycine receptor chloride channel. J.Biol.Chem. 276 12556. PMID: 11278873. Adelsbergeret al (2000) Activation of rat recombinant α1β2γ2S GABAA receptor by the insecticide ivermectin. Eur.J.Pharmacol. 394 163. PMID: 10771281. Khakhet al (1999) Allosteric control of gating and kinetics at P2X4 receptor channels. J.Neurosci. 19 7289. PMID: 10460235. Krauseet al (1998) Ivermectin: a positive allosteric effector of the α7 neuronal nicotinic acetylcholine receptor. Mol.Pharmacol. 53 283. PMID: 9463487. Merck Index 125264. |