| 货号 | 2038/1 |
| 别名 | (5E)-5-[(3aS,4R,5R,6aS)-Hexahydro-5 |
| 是否允许进口 | 否 |
| 是否危险品 | 是 |
| 供应商 | Tocris |
| 生物活性 | Prostacyclin (PGI2) analog that binds with high affinity to IP, EP1 and EP3 receptors (Ki values are 11, 11, 56, 284, 619, 1035, 1870 and 6487 nM for IP, EP1, EP3, EP4, FP, DP, EP2 and TP receptors respectively). Inhibits platelet aggregation induced by collagen, thrombin and ADP (IC50 values are 0.24, 0.71 and 1.07 nM respectively). |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >97 % |
| 计算分子量 | 360.49 |
| 分子式 | C22H32O4 |
| 可溶性/溶解性 | Soluble in methyl acetate (supplied pre-dissolved - 5mg/ml) |
| 参考文献 | Della Bellaet al (2001) Novel mode of action of iloprost: in vitro down-regulaton of endothelial cell adhesion molecules. Prostaglandins Other Lipid Mediat. 65 73. PMID: 11403500. Abramovitzet al (2000) The utilization of recombinant prostanoid receptors to determine the affinities and selectivities of prostaglandins and related analogs. Biochim.Biophys.Acta 1483 285. PMID: 10634944. Schroret al (1981) The antiplatelet and cardiovascular actions of a new carbacyclin derivative (ZK 36 374) - equipotent to PGI2 in vitro. Naunyn-Schmied.Arch.Pharmacol. 316252. |