| 货号 | 4718/100U |
| 是否允许进口 | 否 |
| 是否危险品 | 是 |
| 供应商 | Tocris |
| 生物活性 | Selective NaV1.7 channel blocker. Preferentially inhibits neuronal NaV1.7, 1.2 and 1.3 (IC50 values are 26, 150 and 338 nM respectively), compared to muscle subtypes NaV1.4 and 1.5 (IC50 = >10 μM). Inhibits the channel by binding at the neurotoxin receptor site 4 in the S3-S4 linker of domain II, trapping the voltage sensor in the inward, closed configuration. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 计算分子量 | 4106.79 |
| 分子式 | C174H278N52O |
| 可溶性/溶解性 | Soluble to 1 mg/ml in water |
| 序列号 | ECLEIFKACNPSNDQCCKSSKLVCSRKTRW (Modifications: Disulfide bridge: 2-17,9-24,16-31) (Modifications: Ile-35 = C-terminal amide) |
| 参考文献 | Xiaoet al (2011) Common molecular determinants of tarantula huwentoxin-IV inhibition of Na+ channel voltage sensors in domains II and IV. J.Biol.Chem. 286 27301. PMID: 21659528. Xiaoet al (2008) Tarantula huwentoxin-IV inhibits neuronal sodium channels by binding to receptor site 4 and trapping the domain II voltage sensor in the closed configuration. J.Biol.Chem. 283 27300. PMID: 18628201. |