| 货号 | 5676/100U |
| 是否允许进口 | 否 |
| 是否危险品 | 是 |
| 供应商 | Tocris |
| 生物活性 | Kv2.1 and Kv2.2 channel blocker (IC50 values are 1-3 nM). Enhances glucose-stimulated insulin secretion from human islets in vitro, but not from islet cells lacking the Kv2.1 channel. Has no significant effect on plasma insulin, glucagon or blood glucose levels in mice, but increases plasma somatostatin levels. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 计算分子量 | 3948.61 |
| 分子式 | C178H248N44O |
| 可溶性/溶解性 | Soluble to 1 mg/ml in water |
| 序列号 | EGECGGFWWKCGSGKPACCPKYVCSPKWGL (Modifications: Disulfide bridge: 4-19,11-24,18-31) |
| 参考文献 | Liet al (2013) The role of voltage-gated potassium channels Kv2.1 and Kv2.2 in the regulation of insulin and somatostatin release from pancreatic islets. J.Pharmacol.Exp.Ther. 344 407. PMID: 23161216. Herrington (2007) Gating modifier peptides as probes of pancreatic beta-cell physiology. Toxicon 49 231. PMID: 17101164. |