| 货号 | 0686/100 |
| 别名 | 4a,5,9,10,11,12-Hexahydro-3-methoxy |
| 是否允许进口 | 否 |
| 是否危险品 | 是 |
| 供应商 | Tocris |
| 生物活性 | Long-acting, centrally active acetylcholinesterase inhibitor (IC50 = 410 nM) and allosteric potentiator at neuronal nicotinic ACh receptors. Prevents β-amyloid-induced apoptosis in SH-SY5Y and bovine chromaffin cells. Long-term administration reduces amyloid precursor protein deposition and neurodegeneration in a mouse model of Alzheimer's disease. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >99 % |
| 计算分子量 | 368.27 |
| 分子式 | C17H21NO3.HBr |
| 可溶性/溶解性 | Soluble to 50 mM in water |
| 参考文献 | Ariaset al (2004) Galantamine prevents apoptosis induced by β-amyloid and thapsigargin: involvement of nicotinic acetycholine receptors. Neuropharmacology 46 103. PMID: 14654102. Samochockiet al (2003) Galantamine is an allosterically potentiating ligand of neuronal nicotinic but not of muscarinic acetylcholine receptors. J.Pharmacol.Exp.Ther. 305 1024. PMID: 12649296. Capsoniet al (2002) Nerve growth factor and galantamine ameliorate early signs of neurodegeneration in anti-nerve growth factor mice. Proc.Natl.Acad.Sci.U.S.A. 99 12432. PMID: 12205295. Harvey (1995) The pharmacology of galanthamine and its analogues. Pharmacol.Ther. 68 113. PMID: 8604434. Sweeneyet al (1989) Galanthamine, an acetylcholinesterase inhibitor: a time course of the effects on performance and neurochemical parameters in mice. Pharmacol.Biochem.Behav. 34 129. PMID: 2626444. |