| 货号 | 0655/50 |
| 别名 | N,N,6-Trimethyl-2-(4-methylphenyl)i |
| 是否允许进口 | 否 |
| 是否危险品 | 是 |
| 供应商 | Tocris |
| 生物活性 | Benzodiazepine agonist with high selectivity for α1-subunit-containing GABAA receptors (BZ/ω1 site) and very high intrinsic activity. Ki values are 20, 400 and ≥ 5000 nM for α1-,α2-/α3-, and α5-containing GABAA receptors respectively. Hypnotic that does not induce physical dependence. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >99 % |
| 计算分子量 | 307.39 |
| 分子式 | C19H21N3O |
| 可溶性/溶解性 | Soluble to 100 mM in ethanol and to 50 mM in DMSO |
| 参考文献 | Crestaniet al (2000) Mechanism of action of the hypnotic zolpidem in vivo. Br.J.Pharmacol. 131 1251. PMID: 11090095. Perraultet al (1992) Lack of tolerance and physical dependence upon repeated treatment with the novel hypnotic zolpidem. J.Pharmacol.Exp.Ther. 263 298. PMID: 1403792. Arbillaet al (1986) High affinity [3H]zolpidem binding in the rat brain: an imidazopyridine with agonist properties at central benzodiazepine receptors. Eur.J.Pharmacol. 130 257. PMID: 2878820. Depoortereet al (1986) Zolpidem, a novel nonbenzodiazepine hypnotic. 1. Neuropharmacological and behavioural effects. J.Pharmacol.Exp.Ther. 237 649. PMID: 2871178. |