| 货号 | 4659/50 |
| 别名 | 5-Fluoro-2'-deoxyuridine; FdUrd |
| 是否允许进口 | 否 |
| 是否危险品 | 是 |
| 供应商 | Tocris |
| 生物活性 | Antineoplastic antimetabolite. Exhibits antiproliferative activity; inhibits thymidylate synthetase and disrupts DNA replication in human cells. Induces double-strand DNA breaks; activates ATR and ATM signaling pathways. Induces phosphorylation of Chk1 and Chk2 in OVCAR-8 and SKOV3ip ovarian cancer cell lines. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >98 % |
| 计算分子量 | 246.19 |
| 分子式 | C9H11FN2O5 |
| 可溶性/溶解性 | Soluble to 100 mM in water and to 100 mM in DMSO |
| 参考文献 | Huehlset al (2012) Poly(ADP-ribose) polymerase inhibition synergizes with 5-fluorodeoxyuridine but not 5-fluorouracil in ovarian cancer cells. Cancer Res. 71 4944. PMID: 21613406. Wyatt and Wilson (2009) Participation of DNA repair in the response to 5-fluorouracil. Cell.Mol.Life Sci. 66 788. PMID: 18979208. Bapatet al (1983) Human leukemic cells resistant to 5-fluoro-2'-deoxyuridine contain a thymidylate synthetase with lower affinity for nucleotides. J.Biol.Chem. 258 4130. PMID: 6220000. |