| 货号 | 4385/50 |
| 别名 | 2,3-Dihydro-5,6-dimethoxy-2-[[1-(ph |
| 是否允许进口 | 否 |
| 是否危险品 | 是 |
| 供应商 | Tocris |
| 生物活性 | Potent acetylcholinesterase inhibitor (IC50 = 5.7 nM). Displays 1252-fold selectivity for AChE over BuChE (IC50 = 7138 nM for BuChE). Orally active. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >99 % |
| 计算分子量 | 415.95 |
| 分子式 | C24H29NO3.HCl |
| 可溶性/溶解性 | Soluble to 75 mM in water and to 10 mM in DMSO |
| 参考文献 | Sugimotoet al (2000) Donepezil hydrochloride (E2020) and other acetylcholinesterase inhibitors. Curr.Med.Chem. 7 303. PMID: 10637367. Krygeret al (1999) Structure of acetylcholinesterase complexed with E2020 (Aricept): implications for the design of new anti-Alzheimer drugs. Structure 7 297. PMID: 10368299. Sugimotoet al (1995) Synthesis and structure-activity relationships of acetylcholinesterase inhibitors: 1-benzyl-4-[(5,6-dimethoxy-1-oxoindan-2-yl)methyl]piperidine hydrochloride and related compounds. J.Med.Chem. 38 4821. PMID: 7490731. |