| 货号 | 3976/1 |
| 别名 | 3α,7α,15-Trihydroxy-12,13-epoxytricho |
| 是否允许进口 | 否 |
| 是否危险品 | 是 |
| 供应商 | Tocris |
| 生物活性 | Tricothecene mycotoxin and potent protein synthesis inhibitor. Exhibits cytotoxic activity in vivo via the ribotoxic stress response. Induces p38-mediated gene expression and apoptosis in leukocytes; activity results in systemic expression of interleukin-6 (IL-6) and other proinflammatory cytokines. Also induces migration of NF-κB into the nucleus. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 计算分子量 | 296.32 |
| 分子式 | C15H20O6 |
| 可溶性/溶解性 | Soluble to 30 mM in ethanol |
| 参考文献 | Krishnaswamyet al (2010) Lutein protects HT-29 cells against deoxynivalenol-induced oxidative stress and apoptosis: prevention of NF-κB nuclear localization and down regulation of NF-κB and cyclo-oxygenase-2 expression. Free Radic.Biol.Med. 49 50. PMID: 20347963. Shiet al (2009) Role of GRP78/BiP degradation and ER stress in deoxynivalenol-induced interleukin-6 upregulation in the macrophage. Toxicol.Sci. 109 247. PMID: 19336499. Bae and Pestka (2008) Deoxynivalenol induces p38 interaction with the ribosome in monocytes and macrophages. Toxicol.Sci. 105 59. PMID: 18502741. |