| 货号 | 5292/50 |
| 别名 | (2R,3S,5R)-5-(6-Amino-2-chloropurin |
| 是否允许进口 | 否 |
| 是否危险品 | 是 |
| 供应商 | Tocris |
| 生物活性 | Adenosine deaminase (ADA)-resistant analog of deoxyadenosine. Exhibits anti-leukemic activity; Inhibits cell growth of lymphoid and myeloid neoplasm (IC50 = 20 - 87 nM). Pro-apoptotic; induces DNA double-strand breaks. Also inhibits ribonuclease reductase (IC50 = 0.11 - 0.28 μM). Displays activity in vitroandin vivo. Orally bioavailable. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >99 % |
| 计算分子量 | 285.69 |
| 分子式 | C10H12ClN5O3 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| 参考文献 | Robaket al (2006) Older and new formulations of cladribine. Pharmacology and clinical efficacy in hematological malignancies. Recent Pat. Anticancer Drug Discov. 1 23. PMID: 18221024. Brysonet al (1993) Cladribine. A review of its pharmacodynamic and pharmacokinetic properties and therapeutic potential in haematological malignancies. Drugs 46 872. PMID: 7507037. Setoet al (1985) Mechanism of deoxyadenosine and 2-chlorodeoxyadenosine toxicity to nondividing human lymphocytes. J. Clin. Invest. 75 377. PMID: 2579098. |