| 货号 | 2251/50 |
| 别名 | cis-Diaminodichloroplatinum; CDDP |
| 是否允许进口 | 否 |
| 是否危险品 | 是 |
| 供应商 | Tocris |
| 生物活性 | Potent anticancer agent that blocks DNA synthesis. Induces apoptosis via p53-dependent and -independent mechanisms. Inhibits X-linked inhibitor of apoptosis protein (XIAP) expression and activates caspase-3. In certain glioma cell lines, sensitizes cells to TNF-α-induced apoptosis. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 计算分子量 | 300.05 |
| 分子式 | Cl2H6N2Pt |
| 可溶性/溶解性 | Soluble to 5 mM in water with gentle warming |
| 参考文献 | Duanet al (2004) Impairment of both apoptotic and cytoprotective signalings in glioma cells resistant to the combined use of cisplatin and tumor necrosis factor α. Clin.Cancer Res. 10 234. PMID: 14734475. Nomuraet al (2004) Cisplatin inhibits the expression of X-linked inhibitor of apoptosis protein in human LNCaP cells. Urol.Oncology 22453. Sekiet al (2000) Cisplatin (CDDP) specifically induces apoptosis via sequential activation of caspase-8, -3 and -6 in osteosarcoma. Cancer Chemother.Pharmacol. 45 199. PMID: 10663637. |