| 货号 | 2836/10 |
| 别名 | N-[2-(5-Hydroxy-1H-indol-3-yl)ethyl |
| 是否允许进口 | 否 |
| 是否危险品 | 是 |
| 供应商 | Tocris |
| 生物活性 | Dual fatty acid amide hydrolase (FAAH) inhibitor/TRPV1 antagonist (IC50 values are 5.6 μM and 37 - 40 nM for FAAH and TRPV1 respectively). Inactive at cPLA2, CB1 or 5-HT receptors. Displays strong analgesic activity against both acute and chronic peripheral pain. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 计算分子量 | 462.67 |
| 分子式 | C30H42N2O2 |
| 可溶性/溶解性 | Soluble in methyl acetate (supplied pre-dissolved -10mg/ml) |
| 参考文献 | Maioneet al (2007) Analgesic actions of N-arachidonoyl-serotonin, a fatty acid amide hydrolase inhibitor with antagonistic activity at vanilloid TRPV1 receptors. Br.J.Pharmacol. 150 766. PMID: 17279090. Di Marzoet al (2004) The endocannabinoid system and its therapeutic exploitation. Nat.Rev.Drug Discov. 3 771. PMID: 15340387. Bisognoet al (1998) Arachidonoylserotonin and other novel inhibitors of fatty acid amide hydrolase. Biochem.Biophys.Res.Comms. 248515. |