| 货号 | 0890/100 |
| 别名 | 3,5-Diamino-N-(aminoiminomethyl)-6- |
| 是否允许进口 | 否 |
| 是否危险品 | 是 |
| 供应商 | Tocris |
| 生物活性 | Na+ channel blocker. Defines the I2A-amiloride sensitive and I2B-amiloride insensitive imidazoline binding Blocks TRPP3, acid sensing- (ASIC) and mechanogated membrane-ion channels, as well as the Na+/H+ exchanger. Also inhibits urokinase-type plasminogen activator (uPA); has no effect on tissue-type plasminogen activator. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >98 % |
| 计算分子量 | 266.09 |
| 分子式 | C6H8ClN7O.HCl |
| 可溶性/溶解性 | Soluble to 10 mM in water with gentle warming |
| 参考文献 | Jettiet al (2010) Evaluation of the role of nitric oxide in acid sensing ion channel mediated cell death. Nitric Oxide 22 213. PMID: 20045740. Daiet al (2007) Inhibition of TRPP3 channel by amiloride and analogs. Mol.Pharmacol. 72 1576. PMID: 17804601. Hamill and McBride (1996) The pharmacology of mechanogated membrane ion channels. Pharmacol.Rev. 48 231. PMID: 8804105. Ernsbergeret al (1992) A second generation of centrally acting antihypertensive agents act on putative I1-imidazoline receptors. J.Cardiovasc.Pharmacol. 20S1. Kleymanet al (1988) Amiloride and its analogues as tools in the study of ion transport. J.Membr.Biol. 105 1. PMID: 2852254. Vassalliet al (1987) Amiloride selectively inhibits the urokinase-type plasminogen activator. 214 187. PMID: 3106085. |