| 货号 | 3046/10 |
| 别名 | (3α,5α)-3-Hydroxypregnane-11,20-dione |
| 是否允许进口 | 否 |
| 是否危险品 | 是 |
| 供应商 | Tocris |
| 生物活性 | A neurosteroid anesthetic that directly activates and potentiates GABAA receptor-activated membrane current (IGABA). Efficacy but not potency is determined by the alpha subunit of the receptor (EC50 values are 1.4, 1.8, 2.1, 2.4 and 2.5 μM for α1β1γ3,α1β1γ1,β1γ1,α2β1γ2L and α1β1γ2L isoforms respectively). |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >98 % |
| 计算分子量 | 332.48 |
| 分子式 | C21H32O3 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO and to 100 mM in ethanol |
| 参考文献 | Zechariaet al (2009) The involvement of hypothalamic sleep pathways in general anesthesia: Testing the hypothesis using the GABAA receptor β3N265M knock-in mouse. J.Neurosci. 29 2177. PMID: 19228970. Wegneret al (2007) Auto-modulation of neuroactive steroids on GABAA receptors: a novel pharmacological effect. Neuropharmacology. 52 672. PMID: 17084864. Maitraet al (1999) Subunit dependent modulation of GABAA receptor function by neuroactive steroids. Brain Res. 819 75. PMID: 10082863. |