| 货号 | 2133/1 |
| 是否允许进口 | 否 |
| 是否危险品 | 是 |
| 供应商 | Tocris |
| 生物活性 | Neurotoxin that blocks neuromuscular transmission via irreversible inhibition of nicotinic ACh receptors (nAChRs). Prevents opening of nicotinic receptor-associated ion channels and is selective for α7 receptors over α3β4 receptors (IC50 values are 1.6 nM and > 3 μM respectively). |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 计算分子量 | 7984.14 |
| 分子式 | C338H529N97O |
| 可溶性/溶解性 | Soluble in water |
| 序列号 | IVCHTTATSPISAVTCPPGENLCYRKMWCD (Modifications: Disulfide bridge between 3 - 23, 16 - 44, 29 - 33, 48 - 59, 60 - 65) |
| 参考文献 | Lopezet al (1998) Unmasking the functions of the chromaffin cell α7 nicotinic receptor by using short pulses of acetylcholine and selective blockers. Proc.Natl.Acad.Sci.USA 9514184. Zhanget al (1994) Neuronal acetylcholine receptors that bind α-bungarotoxin with high affinity function as ligand-gated ion channels. Neuron 12 167. PMID: 7507338. |