| 货号 | 319500-500ug |
| 描述 | 11-dehydro TXB2-d4 contains 4 deuterium atoms at the 3, 3, 4, and 4 positions. It is intended for use as an internal standard for the quantification of 11-dehydro TXB2 by GC- or LC-mass spectrometry. TXB2 is released in substantial quantities from aggregating platelets and metabolized during circulation to 11-dehydro TXB2 and 2,3-dinor TXB2.1 11-dehydro TXB2 is one of the main plasma metabolites of TXB2 and can be used as a marker for in vivoTXA2synthesis.1,2,3,4 The mean plasma level in human males is 0.9-4.3 pg/ml and the half life is 45-60 minutes.2,3,4 |
| 别名 | 11-keto TXB2-d4; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Ciabattoni, G.,Pugliese, F.,Davi, G., et al. Fractional conversion of thromboxane B2 to urinary 11-dehydrothromboxane B2 in man. Biochimica et Biophysica Acta 992, 66-70 (1989). 2.Fitzgerald, G.A.,Lawson, J.,Blair, I.A., et al. Analysis of urinary metabolites of thromboxane and prostacyclin by negative-ion chemical-ionization gas chromatography/mass spectrometry. Advances in Prostaglandin, Thromboxane, and Leukotriene Research 15, 87-90 (1985). 3.Takasaki, W.,Nakagawa, A.,Tanaka, Y., et al. Enzyme immunoassay of human plasma 11-dehydrothromboxane B2. Thrombosis Research 63, 331-341 (1991). 4.Catella, F.,Healy, D.,Lawson, J.A., et al. 11-dehydro Thromboxane B2: A quantitative index of thromboxane A2 formation in the human circulation. Proceedings of the National Academy of Sciences of the United States of America 83, 5861-5865 (1986). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥99% deuterated forms (d1-d4) |
| 计算分子量 | 372.5 |
| 分子式 | C20H28D4O6 |
| CAS号 | 1240398-15-5 |
| 稳定性 | ≥ 1 year |
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