Tenovin-6
货号：
13086-25mg 基本售价：
32102.0 元 规格：
25 mg
产品信息
概述| 货号 | 13086-25mg |
| 描述 | The tumor suppressor function of p53 hinges on its ability to function as a transcription factor. Tenovin-6 is an analog of tenovin-1, a small molecule activator of p53 transcriptional activity. At 10 µM, this compound is slightly more effective than tenovin-1 at elevating p53 activity in MCF-7 cells and reduces growth of ARN8 melanoma xenograft tumors in SCID mice at a dose of 50 mg/kg.1 Tenovin-6 inhibits the protein deacetylase activities of purified human SIRT1, SIRT2, and SIRT3 in vitro with IC50 values of 21, 10, and 67 µM, respectively.1 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Lain, S.,Hollick, J.J.,Campbell, J., et al. Discovery, in vivo activity, and mechanism of action of a small-molecule p53 activator. Cancer Cell 13, 454-463 (2008).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 454.6 |
| 分子式 | C25H34N4O2S |
| CAS号 | 1011557-82-6 |
| 稳定性 | ≥ 1 year |
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