| 货号 | 319030-500ug |
| 描述 | Thromboxane B2-d4(TXB2-d4) contains four deuterium atoms at the 3, 3, 4, and 4 positions. It is intended for use as an internal standard for the quantification of TXB2 by GC- or LC-mass spectrometry. TXB2 is a stable, biologically inert metabolite formed from the non-enzymatic hydrolysis of TXA2, which has a half-life of about 30 seconds.1 Urinary analysis of TXB2 accurately reflects intrarenal TXA2synthesis,2 while measurement of 11-dehydro and 2,3-dinor thromboxane metabolites gives the best estimate of systemic TXA2secretion.3,4 |
| 别名 | TXB2-d4; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Needleman, P.,Moncada, S.,Bunting, S., et al. Identification of an enzyme in platelet microsomes which generates thromboxane A2 from prostaglandin endoperoxides. Nature 261, 558-560 (1976). 2.Patrono, C.,Ciabattoni, G.,Patrignani, P., et al. Evidence for a renal origin of urinary thromboxane B2 in health and disease. Advances in Prostaglandin, Thromboxane, and Leukotriene Research 11, 493-498 (1983). 3.Lawson, J.A.,Patrono, C.,Ciabattoni, G., et al. Long-lived enzymatic metabolites of thromboxane B2 in the human circulation. Analytical Biochemistry 155, 198-205 (1986). 4.Patrono, C.,Ciabattoni, G.,Pugliese, F., et al. Estimated rate of thromboxane secretion into the circulation of normal humans. Journal of Clinical Investigation 77, 590-594 (1986). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥99% deuterated forms (d1-d4) |
| 计算分子量 | 374.5 |
| 分子式 | C20H30D4O6 |
| CAS号 | 1346112-79-5 |
| 稳定性 | ≥ 1 year |
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