| 货号 | 9000686-50mg |
| 描述 | 17-phenyl trinor Prostaglandin F2α (17-phenyl trinor PGF2α) is a metabolically stable, potent agonist of the PGF (FP) receptor.1,2 FP agonists can be effective in modulating intraocular pressure, luteolysis, and parturition.3,4,5 17-phenyl trinor PGF2α cyclohexyl amide is a form of 17-phenyl trinor PGF2α with a modification of the α carbon. The addition of a cyclohexane moiety at this position strongly decreases its solubility in aqueous media, leaving it soluble solely in organic solvents. The activity of this compound at the FP receptor has not been evaluated. |
| 别名 | Bimatoprost cyclohexyl amide; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Balapure, A.K.,Rexroad, C.E., Jr.,Kawada, K., et al. Structural requirements for prostaglandin analog interaction with the ovine corpus luteum prostaglandin F2α receptor. Biochemical Pharmacology 38, 2375-2381 (1989). 2.Lake, S.,Gullberg, H.,Wahlqvist, J., et al. Cloning of the rat and human prostaglandin F2α receptors and the expression of the rat prostaglandin F2α receptor. FEBS Letters 355, 317-325 (1994). 3.Stjernschantz, J., and Resul, B. Phenyl substituted prostaglandin analogs for glaucoma treatment. Drugs of the Future 17, 691-704 (1992). 4.Dukes, M.,Russell, W., and Walpole, A.L. Potent luteolytic agents related to prostaglandin F2α. Nature 250, 330-331 (1974). 5.Kobayashi, T., and Narumiya, S. Function of prostanoid receptors: Studies on knockout mice. Prostaglandins & Other Lipid Mediators 68-69, 557-573 (2002). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 469.7 |
| 分子式 | C29H43NO4 |
| 稳定性 | ≥ 2 years |
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