15(R)-17-phenyl trinor Prostaglandin F2α isopropyl ester
货号：
16825-50mg 基本售价：
28910.0 元 规格：
50 mg
产品信息
概述| 货号 | 16825-50mg |
| 描述 | 15(R)-17-phenyl trinor Prostaglandin F2α isopropyl ester (15(R)-17-phenyl trinor PGF2α isopropyl ester) is the latanoprost-related isomer containing both a double bond at 13,14 and an inverted (β) hydroxyl group at C-15. Similar to 15(S)-latanoprost, 15(R)-17-phenyl trinor PGF2α isopropyl ester is a potential impurity in most commercial preparations of the latanoprost bulk drug product. The IC50 values for the free acid forms of 15(S)-17-phenyl trinor PGF2α and 15(R)-17-phenyl trinor PGF2α were determined to be 0.71 nM and 30 nM, respectively, in a FP receptor binding assay using the cat iris sphincter muscle.1 A 3 µg dose of 15(R)-17-phenyl trinor PGF2α caused a 1.9 mmHg reduction of IOP in normotensive cynomolgus monkeys.1 |
| 别名 | 15-epi Bimatoprost isopropyl ester;15(R)-Bimatoprost isopropyl ester;15(R)-17-phenyl trinor PGF2α isopropyl ester; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Resul, B.,Stjernschantz, J.,No, K., et al. Phenyl-substituted prostaglandins: Potent and selective antiglaucoma agents. Journal of Medicinal Chemistry 36, 243-248 (1993).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 430.6 |
| 分子式 | C26H38O5 |
| CAS号 | 130273-87-9 |
| 稳定性 | ≥ 2 years |
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